HSS Research Institute
Since its founding more than 150 years ago, Hospital for Special Surgery has been a leader in research aimed at improving the lives of patients suffering from debilitating orthopedic and rheumatic conditions such as arthritis, bone and soft tissue injuries, autoimmune diseases, and musculoskeletal pain and deformities.
Today, the HSS Research Institute, with over 225 dedicated personnel, is identifying mechanisms underlying these conditions, and developing effective approaches for prevention, diagnosis, and treatment. With a focus on tissue repair, improving surgical outcomes, autoimmunity and inflammation, genomics, new treatments, and precision medicine, the impact of our discoveries – many of which are only happening at HSS – determine future directions of musculoskeletal research to best improve clinical outcomes.
Active Federal Grants Funding
Publications in 2023
Active Foundation & Industry Funding
We are embarking on a new era of research at HSS by expanding the scope of basic and clinical science and building multidisciplinary translational research teams.
Research Areas
Skeletal Health and Orthopedic Research
Inflammation and Autoimmunity
Soft Tissue
Biomechanics
Genomics
MRI Research
Precision Medicine
Making health care personal
In response to the great promise that precision medicine holds, HSS has created a Precision Medicine Laboratory that will enable the study of disease mechanisms, surgical outcomes, and responses to therapy in specific patient populations. The Laboratory catalyzes the formation of multidisciplinary teams of scientists, physicians, and orthopaedic surgeons, linking clinical research with exciting basic science research. HSS will use the precision medicine approach to pinpoint the most personalized treatment plan for the patient – ultimately allowing physicians to select the right treatment the first time and improving outcomes.
Precision Medicine Laboratory
- Laura Donlin, PhD and Miguel Otero, PhD, Directors
Through the HSS Precision Medicine Laboratory, multidisciplinary clinician-scientist teams comprehensively study orthopedic and autoimmune disorders. Through integrative and cutting-edge approaches, we aim to discover the best treatment for each patient.
Movement is the Essence of Life
HSS Research In the News
- HSS Patient Outcomes Research Highlights Ongoing Commitment to Accurate Reporting and Patient Safety
- HSS Research Shows “Quiet Knee” Protocol Could Redefine Knee Replacement Recovery
- HSS Presents New Research at The American Association of Hip and Knee Surgeons Annual Meeting
- Hospital for Special Surgery Study Shows AI Tool Effectively Prepares Patients for Joint Replacement Surgery
- When Age and Heart Failure Crash the DDD Party
- Social Isolation a Common Theme Among Older People With SLE
- Machine learning may assist in identifying pain trajectories after TKA
- HSS Achieves 100% Success Rate for Sedation-Free Pediatric MRIs
- Knee implants may have high long-term survivability in young patients
- Two HSS Studies Exploring Pain Control Win President’s Choice Awards at Annual ASRA Meeting
- HSS Studies Identify Potential Profile and Treatment Options for Mild Traumatic Brain Injury
- HSS Names Kevin M. Koch, PhD, Founding Director of the Applied Sciences Institute and Vice Chair of Research in Radiology
- New Study Reveals Young, Active Patients Who Have Total Knee Replacements are Unlikely to Need Revision Surgery in their Lifetime
- Tibial tubercle transfer associated with low complication risk with, without distalization
- Trials Aim to Show Benefit of Orthobiologic for Knee OA
- GLP-1 receptor agonists may improve outcomes for patients with morbid obesity after TKA
- HSS Participates in Promising Phase 3 Lupus Trial of Investigational Therapy DZP
- Proximal femoral replacement may effectively salvage complex revision THA cases
- Study Shows Knee Osteoarthritis Causes More Pain and Inflammation in Women
- HSS Presents Cutting-Edge Discoveries in Rheumatic Disease and Reproductive Health at ACR Convergence 2024
- Study Shows Avacopan Effective for Most Serious Vasculitis Cases
- Surprising Study Finds No Link Between Rheumatoid Arthritis and Transfusion Risk After Knee Replacement
- New Research Reveals Alterations in Blood of People at Risk of Developing Rheumatoid Arthritis
- HSS Presents New Research at the ACR Convergence 2024
- New Study Signals How Online Search Trends Could Lead to More Personalized Rheumatic Disease Care
- Pregnancy can change your feet forever. Here's the science behind 'mom feet.'
- Novel Drug Candidate Based on HSS Research Secures $70M Series A Financing and Will Begin Its First Clinical Trial in Europe
- HSS Launches Clinical Trial to Address Post-Traumatic Osteoarthritis after ACL Revision Surgery
- Dr. Kyle Kunze- Growing in Residency
- Liposomal bupivacaine may augment pain management for spinal fusion
- HSS Celebrates Women's History Month (Dr. Suzanne Maher)
- Self-reported nickel allergy may not impact outcomes after TKA
- ChatGPT-4 may provide accurate, reliable patient information on the Latarjet procedure
- New HSS Studies Highlight the Benefits of Robotic-Assisted Joint Replacement Surgery
- HSS Presents Research at 2024 AAOS Annual Meeting
- HSS Research Evaluates Whether AI Chatbots Provide Reliable Medical Information
- Meet Us At Tomorrow: Discovery, Learning, & Leadership for the Future of Orthopaedics (HSS)
- Study Assesses Sarilumab for Polymyalgia Rheumatica
- HSS Study Reveals Concerning Link Between Growth Hormone Therapy and Growth Plate Fractures in Children
- Dr. Elizabeth Gausden joins Doctor Podcast
- Revamped ACR-EULAR Antiphospholipid Syndrome Classification Criteria: What Do They Mean for Clinical Research?
- HSS to Harness Surge in Artificial Intelligence Applications and Democratize High Quality Healthcare
- HSS Researchers Enable Study Identifying Subtypes of Rheumatoid Arthritis
- HSS Presents New Reproductive Health Research at the ACR Convergence 2023
- HSS Shares Strategies to Enhance and Enable Communication with Language-Diverse Patients at Annual ACR Convergence
- New Antiphospholipid Syndrome Research Findings Presented at ACR Convergence 2023
- New Study Identifies Outcomes Associated With Frailty in Patients With Vasculitis
- New Study Shows Perception of Aging is Linked to Level of Physical Activity in Arthritis Patients
- Study Finds People with Inflammatory Arthritis Face Significant Psychological Challenges in Maintaining Employment
- HSS Research Shows Obesity Is Associated with Worse Flare Symptoms and Quality of Life in People with Early Rheumatoid Arthritis