Clinical Trials / Research Studies by Topic

Please find clinical trials at HSS listed by the following topics or view the full directory.

APS (Antiphospholipid Syndrome)
Arthritis
Foot and Ankle Conditions
Hip and Knee Conditions
Lupus
Myositis
Osteoporosis
Rheumatoid Arthritis
Spine Conditions
Skeletal Dysplasias
Scleroderma
Vasculitis

Non-orthopedic and non-rheumatologic clinical trials are conducted at Weill Cornell Medical College, an affiliate of Hospital for Special Surgery.

APS (Antiphospholipid Syndrome)

PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)

Jane E. Salmon, MD

2014-309

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

Autoimmune Disease Registry and Repository

Jane E. Salmon, MD

2014-306

The IMPACT Study: IMProve Pregnancy in APS with Certolizumab Therapy

Jane E. Salmon, MD

2017-0317

APS ACTION (Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking) International Clinical Database and Repository.

Doruk Erkan, MD, MPH

2014-252

Arthritis

The Women’s Soccer and Basketball Health Study: From Head to Toe

Ellen Casey, MD, CAQSM, FACSM

2020-1747

The Established Rheumatoid Arthritis Cohort

Susan M. Goodman, MD

2014-234

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

A 48-Week, Phase 2b/3a, Double-Blind, Randomized, Placebo Controlled, Multi-center, Superiority Study to Evaluate the Efficacy and Safety of JointStem, Autologous Adipose Tissue Derived Mesenchymal Stem Cells in patients diagnosed with Knee Osteoarthritis

Sabrina M. Strickland, MD

2021-0514

ASA (ReNu) Efficacy" Organogenesis Inc. Study: “A Phase 3 Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy of Amniotic Suspension Allograft (ASA) in Patients with Osteoarthritis of the Knee”

Andreas H. Gomoll, MD

2020-2278

Foot and Ankle Conditions

Foot and Ankle Registry

Jonathan T. Deland, MD

2013-038

Hip and Knee Conditions

Pediatric and Adolescent Patellofemoral Instability

Beth E. Shubin Stein, MD

2014-087

Mpfl Reconstruction for Recurrent Patellofemoral Instability: Rates of Failure vs. Radiographic Parameters

Beth E. Shubin Stein, MD

2013-112

The Center for Hip Preservation Outcomes Registry

Bryan T. Kelly, MD, MBA

2014-044

Effect of Duloxetine on Opioid use after Total Knee Arthroplasty. A Double-blinded Randomized Control Trial

Jacques T. YaDeau, MD, PhD

2017-0655

Lupus

A 5-Year Prospective Observational Registry to Assess Adverse Events of Interest and Effectiveness in Adults with Active, Autoantibody-Positive Systemic Lupus Erythematosus Treated with or without BENLYSTA™ (belimumab)

Doruk Erkan, MD, MPH

2015-090

Systemic Lupus Erythematosus (SLE) Treatment with N-acetylcysteine (NAC) (SNAC)

Kyriakos A. Kirou, MD, DSc, FACP

2021-1594

Undifferentiated Connective Tissue Disease (UCTD) and Overlap Registry

Lisa R. Sammaritano, MD

2014-311

Can Body Composition Help us Better Understand Outcomes in People with Lupus?

Lisa A. Mandl, MD, MPH

2017-1061

Immune System Regulation in Autoimmune and Inflammatory Diseases

Mary K. Crow, MD

2014-221

Studies of Immune Deregulation in Patients with SLE

Alessandra Pernis, MD

2014-299

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

A Phase 3 Randomized. Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Deucravacitinib in Participants with Active Systemic Lupus Erythematosus (SLE) (POETYK SLE-2)

Kyriakos A. Kirou, MD, DSc, FACP

2023-0229

A Novel Phase 2 Double-Blind, Randomized, Controlled Clinical Trial to Evaluate the Efficacy of Centrally Acting, Non-Toxic ACE Inhibition in Cognitive Impairment Associated with SLE

Kyriakos A. Kirou, MD, DSc, FACP

2020-0226

Autoimmune Disease Registry and Repository

Jane E. Salmon, MD

2014-306

ELUCIDATE-Epigenetics; Lupus Urine Cells in Decoding APOL1 Transmutation Effect

Ashira Blazer, MD

2022-0690

SLE - AWARE: SLE - A Window into APOL1 Regulation and Expression

Ashira D. Blazer, MD, MSCI

2022-0639

PKRG1 in SLE

Timothy B. Niewold, MD, FACR

2022-1251

Please visit the Mary Kirkland Center for Lupus Research and the Lupus Clinical Trials Consortium for more information on lupus research.

Myositis

A Phase II/III Randomized, Double-blind, Placebo-controlled, Multicenter Study to Determine the Efficacy and Safety of ABC008 in the Treatment of Subjects with Inclusion Body Myositis

David R. Fernandez, MD, PhD

2023-0068

The Myositis Registry and Repository - 2016

David R. Fernandez, MD, PhD

2014-263

Osteoporosis

The Women’s Soccer and Basketball Health Study: From Head to Toe

Ellen Casey, MD, CAQSM, FACSM

2020-1747

Fragile Bone Registry

Joseph M. Lane, MD

2015-165

Rheumatoid Arthritis

Perioperative Flare in Rheumatoid Arthritis: Characterization of Clinical and Biologic Features

Susan M. Goodman, MD

2014-233

Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis

Alessandra Pernis, MD

2014-312

Consortium of Early Arthritis Cohorts USA (CATCH-US) – A prospective cohort study of adults with new onset inflammatory arthritis symptoms to understand predictors of optimal outcomes

Vivian P. Bykerk, BSc, MD, FRCPC

2014-229

The Established Rheumatoid Arthritis Cohort

Susan M. Goodman, MD

2014-234

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

Predicting TREATment in Inflammatory Arthritis

Theresa Wampler Muskardin, MD

2022-1201

Scleroderma

VCRC Genetic Repository One Time DNA Protocol - 2016

Robert F. Spiera, MD

2014-278

Scleroderma Patient Centered Intervention Network (SPIN)

Robert F. Spiera, MD

2014-326

Scleroderma Registry and Repository

Robert F. Spiera, MD

2014-276 (previously 26069)

Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension

Jessica K. Gordon, MD

2014-265

Scleroderma Cyclophosphamide or Transplantation (SCOT) Study

Robert F. Spiera, MD

26002

The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience

Jillian Rose, PhD, MPH, LCSW

2020-0956

VCRC Genetic Repository One Time DNA Protocol - 2013

Robert F. Spiera, MD

2014-278

A Double Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of PRA023 in Subjects with Systemic Sclerosis Associated with Interstitial Lung Disease (Ssc-ILD)

Jessica K. Gordon, MD

2022-0436

A Randomized, Double-Blind, Placebo-Controlled Study of Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis

Robert F. Spiera, MD

2018-2011

Skeletal Dysplasias

The Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Clinical Research Registry

Cathleen L. Raggio, MD

2014-166

Spine Conditions

Prospective, Concurrently Controlled, Multi-Center Study to Evaluate the Safety and Effectiveness of the Spinal KineticsTM M6-C Artificial Cervical Disc Compared to Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Symptomatic Cervical R

Andrew A. Sama, MD

2014-104

A Prospective Analysis of Connective Tissue Factors and Outcomes in Lumbar Spinal Fusion: A Pilot Study

Alexander P. Hughes, MD

2014-084

Genetic Mapping Studies of Adolescent Idiopathic Scoliosis

Cathleen L. Raggio, MD

2014-375

Vasculitis

Abatacept (CTLA4-lg) for the Treatment of Relapsing, Non Severe, Granulomatosis with Polyangiitis (Wegener’s) (ABROGATE)

Robert F. Spiera, MD

2015-267

Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis

Alessandra Pernis, MD

2014-312