Does Pregabalin Reduce Pain after Ankle Surgery?

IRB Number: 28086

inactive

July 06, 2011

Institutional Review Board, Hospital for Special Surgery

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Principal Investigator

Kethy M. Jules-Elysee, MD

Co-Investigators

Kethy M. Jules-Elysee, MD
Richard L.Kahn, MD
Vincent R.Lasala, MD
David S Levine, MD
Spencer Liu, MD
Leonardo Paroli, MD, PhD
Matthew M.Roberts, MD
Edward Lin, MD
Barbara Wukovits, RN, BSN
yadeauj@hss.edu

Summary

Inclusion/Exclusion Criteria

Inclusion Criteria:
• Patients of Dr Levine or Dr Roberts.
• Scheduled for admission after foot or ankle surgery.
• A single-injection sciatic nerve block in the popliteal fossa is judged appropriate.
• Surgery confined to foot and ankle (no iliac crest bone graft planned - iliac aspirate is not an exclusion criterion).
• Age ≥ 18 years

Exclusion Criteria:
• Surgery that will cause pain at sites outside the distal lower extremity (e.g. iliac crest bone graft).
• Chronic pain (defined as regular use of opioid analgesics for > 3 months).
• Contraindication to performance of the PFNB.
• Contraindication to a 30 cc 0.375% bupivacaine PFNB (e.g. alleged bupivacaine sensitivity, low body weight, etc.).
• Contraindication to use of clonidine or hydromorphone (e.g. allergy).
• Preoperative current use of pregabalin or gabapentin (“Neurontin”)
• Intolerance to pregabalin or gabapentin
• Inability of the patient to describe postoperative pain (e.g. psychiatric disorder, dementia).
• Non-English speaking patients (the questionnaire is in English, and translations would have to be separately validated)

Contact Information

Jacques T. YaDeau, MD
yadeauj@hss.edu
212.606.1206